Mapping EK Draconis with PEPSI - Possible evidence for starspot penumbrae

We present the first temperature surface map of EK Dra from very-high-resolution spectra obtained with the Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope. Changes in spectral line profiles are inverted to a stellar surface temperature map using our $i$Map code. The long-term photometric record is employed to compare our map with previously published maps. Four cool spots were reconstructed, but no polar spot was seen. The temperature difference to the photosphere of the spots is between 990 and 280K. Two spots are reconstructed with a typical solar morphology with an umbra and a penumbra. For the one isolated and relatively round spot (A), we determine an umbral temperature of 990K and a penumbral temperature of 180K below photospheric temperature. The umbra to photosphere intensity ratio of EK Dra is approximately only half of that of a comparison sunspot. A test inversion from degraded line profiles showed that the higher spectral resolution of PEPSI reconstructs the surface with a temperature difference that is on average 10% higher than before and with smaller surface areas by 10-20%. PEPSI is therefore better suited to detecting and characterising temperature inhomogeneities. With ten more years of photometry, we also refine the spot cycle period of EK Dra to 8.9$\pm$0.2 years with a continuing long-term fading trend. The temperature morphology of spot A so far appears to show the best evidence for the existence of a solar-like penumbra for a starspot. We emphasise that it is more the non-capture of the true umbral contrast rather than the detection of the weak penumbra that is the limiting factor. The relatively small line broadening of EK Dra, together with the only moderately high spectral resolutions previously available, appear to be the main contributors to the lower-than-expected spot contrasts when comparing to the Sun.Comment: Accepted for A&

Asymmetricity of ground-based GPS slant delay data

International audienceThe ground-based measurements of the Global Positioning System (GPS) allow estimation of the tropospheric delay along the slanted signal paths through the atmosphere. The meteorological exploitation of such slant delay (SD) observations relies on the hypothesis of azimuthal asymmetry of the information content. This article addresses the validity of the hypothesis. A new concept of asymmetricity is introduced for studying the SD observations and their model counterparts. The asymmetricity is defined as the ratio of the absolute asymmetric delay component to total SD. The model counterparts are determined from 3-h forecasts of a numerical weather prediction (NWP) model, run with four different horizontal resolutions. The SD observations are compared with their model counterparts with emphasis on cases of high asymmetricity in order to see whether the observed asymmetry is a real atmospheric signature. The asymmetricity is found to be of the order of a few parts per thousand. Thus, the asymmetric delay component barely exceeds the assumed standard deviation of the SD observation error. However, the observed asymmetric delay components show a statistically significant meteorological signal. Benefit of the asymmetric SD observations is therefore expected to be taken in future, when NWP systems will explicitly represent the small-scale atmospheric features revealed by the SD observations

Azimuthal asymmetry in ground-based GPS slant delay observations and their NWP model counterparts

International audienceThe ground-based measurements of the Global Positioning System (GPS) allow estimation of the tropospheric delay along the slanted signal paths through the atmosphere. The meteorological exploitation of such slant delay (SD) observations relies on the hypothesis of azimuthal asymmetry of the information content. This article addresses the validity of the hypothesis. The asymmetric properties of the SD observations and their model counterparts are investigated. In this study, the model counterparts are based on 3-h forecasts of a numerical weather prediction (NWP) model, run with four different horizontal resolutions. The SD observations are compared with their model counterparts with emphasis on cases of high asymmetry in order to see whether the observed asymmetry is a real atmospheric signature. The asymmetric delay component is found to be of the order of a few parts per thousand of the absolute SD value, thus barely exceeding the assumed standard deviation of the SD observation error. However, the observed asymmetric delay components show a statistically significant meteorological signal. Benefit of the asymmetric SD observations is therefore expected to be taken in future, when NWP systems will explicitly represent the small-scale atmospheric features revealed by the SD observations

Renal Tumor Invasion Depth and Diameter are the Two Most Accurate Anatomical Features Regarding the Choice of Radical Versus Partial Nephrectomy

Background and Aims: To evaluate simple tumor characteristics (renal tumor diameter and parenchymal invasion depth) compared with more complex classifications, that is, Renal Tumor Invasion Index (RTII) and Preoperative Aspects and Dimensions Used for an Anatomical classification, in predicting the type of nephrectomy (radical vs partial) performed. Material and Methods: A total of 915 patients who had undergone either partial nephrectomy (n=388, 42%) or radical nephrectomy (n=527, 58%) were identified from the Helsinki University Hospital kidney tumor database between 1 January 2006 and 31 December 2014. Tumor maximum diameter and depth of invasion into the parenchyma were estimated from computed tomography or magnetic resonance imaging images and compared with Preoperative Aspects and Dimensions Used for an Anatomical and Renal Tumor Invasion Index. Logistic regression and receiver operating curves were used to compare the parameters at predicting the type of nephrectomy. Results and conclusion: All the anatomical variables of receiver operating curve/area under the curve analyses were significant predictors for the type of nephrectomy. Parenchymal invasion (area under the curve 0.91; 95% confidence interval, 0.89-0.93), RTII (area under the curve 0.91; 95% confidence interval, 0.89-0.93), and diameter (area under the curve 0.91; 95% confidence interval, 0.89-0.93) performed significantly better than Preoperative Aspects and Dimensions Used for an Anatomical classification (area under the curve 0.88; 95% confidence interval, 0.85-0.89). In multivariable analysis, invasion depth was the best predictor of nephrectomy type (percentage correct, 85.6%). Addition of one anatomic parameter into the model of non-anatomical cofactors improved the accuracy of the model significantly, but the addition of more parameters did not. Parenchymal invasion depth and tumor diameter are the most accurate anatomical features for predicting the nephrectomy type. All potential anatomical classification systems should be tested against these two simple characteristics.Peer reviewe

Fibrinolytic and coagulative activities of Yersinia pestis

Peer reviewe

Validation of 3D echocardiographic volume detection of left atrium by human cadaveric casts

Background: Left atrial volume is a prognostic factor in cardiac pathologies. We aimed to validate left atrial volume detection with 3D and 2D echocardiography (3DE and 2DE) by human cadaveric casts. 3DE facilitates measurement of atrial volume without geometrical assumptions or dependence on imaging angle in contrast to 2DE methods. Methods: For method validation, six water-filled balloons were submerged in a 20-l water tank and their volumes were measured with 3DE. Seven human cadaveric left atrial casts were prepared of silicone and were transformed into ultrasound-permeable casts. Casts were imaged in the same setting, so that 3DE and 2DE of casts represented transthoracic apical view. Left ventricle analysis softwares GE 4D Auto LVQ and TomTec 4D LV-Function were used for 3DE volumetry. Results; Balloon volumes ranged 37 to 255ml (mean 126 ml). 3DE resulted in an excellent volumetric agreement with balloon volumes, absolute bias was -3.7 ml (95% CI -5.9 to -1.4). Atrial cast volumes were 38 to 94 ml (mean 56.6 ml). 3DE and 2DE volumes were excellently correlated with cast volumes (r = 0.96 to 0.99). Biases were for GE 4D LVQ - 0.7 ml (95% CI -6.1 to 4.6), TomTec 4D LV-Function 3.3 ml (-1.9 to 8.5) and 2DE 2.9 ml (-4.0 to 9.9). 3DE resulted in lower limits of agreement and showed no volume-related bias in contrast to area-length method. Conclusions: We conclude that measurement of human cadaveric left atrial cast volumes by 3DE is in excellent agreement with true cast volumes.Peer reviewe

Osteoporosis : the emperor has no clothes

Current prevention strategies for low-trauma fractures amongst older persons depend on the notions that fractures are mainly caused by osteoporosis (pathophysiology), that patients at high risk can be identified (screening) and that the risk is amenable to bone-targeted pharmacotherapy (treatment). However, all these three notions can be disputed. PathophysiologyMost fracture patients have fallen, but actually do not have osteoporosis. A high likelihood of falling, in turn, is attributable to an ageing-related decline in physical functioning and general frailty. ScreeningCurrently available fracture risk prediction strategies including bone densitometry and multifactorial prediction tools are unable to identify a large proportion of patients who will sustain a fracture, whereas many of those with a high fracture risk score will not sustain a fracture. TreatmentThe evidence for the viability of bone-targeted pharmacotherapy in preventing hip fracture and other clinical fragility fractures is mainly limited to women aged 65-80years with osteoporosis, whereas the proof of hip fracture-preventing efficacy in women over 80years of age and in men at all ages is meagre or absent. Further, the antihip fracture efficacy shown in clinical trials is absent in real-life studies. Many drugs for the treatment of osteoporosis have also been associated with increased risks of serious adverse events. There are also considerable uncertainties related to the efficacy of drug therapy in preventing clinical vertebral fractures, whereas the efficacy for preventing other fractures (relative risk reductions of 20-25%) remains moderate, particularly in terms of the low absolute risk reduction in fractures with this treatment.Peer reviewe